教 师 简 历
基本信息
照片/Photo：
电子邮箱/E-mail：jiangbosong@swu.edu.cn
个人简介
致力于家蚕分子生理学及实验动物化研究，并以寿命调控、延寿药物评价和疾病模型构建为主要内容，推进家蚕模式化应用。主持国家自然科学基金项目2项（面上、青年各1项）、西南大学基础学科“U40”青年人才科技项目等各类科研项目6项。以第一作者发表SCI论文11篇（大类一区5篇），发现长寿调节新基因OSER1，阐明了其在多个物种中响应氧化应激的作用机理，揭示了其抗衰延寿的保守性新机制，为推动家蚕作为探究人类衰老与疾病研究的实验动物奠定了重要基础，该项成果已被Nature子刊Nat Commun接受。此外，研究建立了家蚕作为延寿中药效应评价系统和帕金森综合症家蚕模型，分别发表在BMC Med（1区，IF=11.8）、J Pharm Anal（1区，IF=14.02）、Aging Dis（1区，IF=9.96）等知名期刊。申请国家发明专利1项。积极推动国际合作，筹措举行国际学术研讨会2次；承办国内区域性学术会联会1次，做国际学术报告5次，国内学术报告1次。为国家蚕桑产业技术体系高产优质品种改良岗位团队成员、《农业生物技术学报》青年编委、重庆市昆虫学会理事、中国遗传学会会员、BMC Genomics等期刊审稿人。
课程教学
本科生课程：
1. 生物化学与分子生物学基础（英文），课程负责人，西塔学院
2. 细胞工程（双语），课程负责人，西塔学院
3. 生命科学前沿，课程参与人，西塔学院
研究方向及课题
1. 以家蚕为研究对象，结合经典模式动物探究衰老和寿命调节的保守性分子机制
2. 以家蚕为实验动物发掘疾病基因，构建疾病模型、评价药物药效和药理
研究成果
代表性科研项目：
[1] 国家自然科学基金面上项目，项目名称：BmOSER1通过调节氧化应激影响雄蚕蛾育性的分子机理研究，课题编号：32272939，起止年月：2023.01-2026.12，主持。
[2] 国家自然科学基金青年基金项目，项目名称：BmFoxO靶基因BmOSER1在家蚕氧化压力应答中的功能及作用机制研究，课题编号：20192215，起止年月：2020.01-2022.12，主持。
[3] 重庆市博士后科研特别资助项目，项目名称：基于特定motif的FoxO靶基因的全基因组鉴定和功能研究，课题编号：Xm2018058；起止年月：2018.10-2020.06；主持。
[4] 西南大学中央高校基本科研业务费基础学科青年人才项目（简称U40），项目名称：“生命蚕”——利用家蚕挖掘寿命调控新基因，课题编号：SWU-KU24007；起止年月：2024.07-2027.06，主持。
[5] 中央高校基本业务费一般项目，项目名称：二甲双胍调控家蚕寿命的分子机制研究，课题编号：XDJK2019C014；起止年月：2019.03-2020.12；主持。
[6] 西南大学博士启动（含引进人才计划）项目，项目名称：OSER1基因调控寿命的机制研究，课题编号：SWU120064；起止年月：2021.05-2022.12；主持。
代表性学术论文：
[1] Jiangbo Song*, Zhiquan Li*, Lei Zhou, Xin Chen, Wei Qi Guinevere Sew, Héctor Herranz, Zilu Ye, Jesper Velgaard Olsen, Yuan Li, Marianne Nygaard, Kaare Christensen, Xiaoling Tong, Vilhelm A. Bohr, Lene Juel Rasmussen§, Fangyin Dai§. FOXO-regulated OSER1 reduces oxidative stress and extends lifespan in multiple species. Nature Communications. 2024, In production.
[2] Song Jiangbo*, Liu Lian*, Li Zhiquan *, Mao Ting, Zhang Jianfei, Zhou Lei, Chen Xin, Shang Yunzhu, Sun Tao, Luo Yuxin, Jiang Yu, Tan Duan, Tong Xiaoling and Dai Fangyin§. Lycium barbarum polysaccharide improves dopamine metabolism and symptoms in an MPTP-induced model of Parkinson’s disease. BMC Medicine. 2022, 20: 412. Doi:10.1186/s12916-022-02621-9
[3] Song Jiangbo*, Chen Min*, Li Zhiquan, Zhang Jianfei, Hu Hai, Tong Xiaoling§, Dai Fangyin§. Astragalus Polysaccharide extends lifespan via mitigating endoplasmic reticulum stress in the Silkworm, Bombyx mori. Aging and Disease. 2019, 10(2): 1187-1198.
[4] Song Jiangbo*, Liu Lian*, Hao Kaige, Mao Shuang, Tang Yongxi, Tong Xiaoling, Dai Fangyin§. Resveratrol elongates the lifespan and improves antioxidant activity in the silkworm, Bombyx mori. Journal of Pharmaceutical Analysis. 2021, 11: 374-382.
[5] Song Jiangbo*, Jiang Guihua*, Zhang Jianfei, Guo Jieshu, Li Zheng, Hao Kaige, Liu Lian, Cheng Zilin, Tong Xiaoling, Dai Fangyin§. Metformin prolongs lifespan through remodeling the energy distribution strategy in silkworm, Bombyx mori. Aging-US, 2019, 11(1): 240-248.
[6] Song Jiangbo*, Hao Kaige*, Chen Xin, Zhang Yanhua, Cheng Zilin, Mao Shuang, Tang Yongxi, Tong Xiaoling and Dai Fangyin§. Fibroblast growth factor 21 prolongs lifespan and improves stress tolerance in the silkworm, Bombyx mori. Annals of Translational Medicine. 2020, 8(5): 220.
[7] Song Jiangbo*, Li Zhiquan*, Tong Xiaoling, Chen Cong, Chen Min, Meng Gang, Chen Peng, Li Chunlin, Dai Fangyin§. Genome-wide identification and characterization of Fox genes in the silkworm, Bombyx mori. Functional & Integrative Genomics. 2015, 15(5):511-522.
[8] Song Jiangbo, Zhang Jianfei, Dai Fangyin§. Advantages and limitations of silkworm as an invertebrate model in aging and lifespan research. Invited, Open Access Journal of Gerontology & Geriatric Medicine. 2018, 4(4): ID.555641.
[9] Zhiquan Li*, Jiangbo Song*, Guihua Jiang, Yunzhu Shang, Yu Jiang, Jianfei Zhang, Li Xiao, Min Chen, Dongmei Tang, Xiaoling Tong, Fangyin Dai§. Juvenile hormone suppresses the FoxO-takeout axis to shorten longevity in male silkworm. Pesticide Biochemistry and Physiology. 2023, 192: 105388.
[10] Jianfei Zhang*, Zhiquan Li*, Jiangbo Song*, Lei Zhou, Xin Chen, Wen Ge, Tianyi Dong, Yuxin Luo, Ting Mao, Zheng Li, Duan Tan, Lene Juel Rasmussen, Vilhelm A. Bohr, Xiaoling Tong, Fangyin Dai§. Salidroside promotes healthy longevity by interfering with HSP90 activity. GeroScience. 2023, Accepted.
[11] Chen Cong*, Song Jiangbo*, Chen Min, Li Zhiquan, Tong Xiaoling, Hu Hai, Xiang Zhonghuai, Lu Cheng, Dai Fangyin§. Rhodiola rosea extends lifespan and improves stress tolerance in silkworm, Bombyx mori. Biogerontology. 2016, 17: 373-381.
[12] Jiang Guihua, Song Jiangbo, Hu Hai, Tong Xiaoling and Dai Fangyin§. Evaluation of the silkworm lemon mutant as an invertebrate animal model for human sepiapterin reductase deficiency. Royal Society Open Science. 2020, 7(3): 191888.
[13] Li Zheng, Song Jiangbo, Zhang Jianfei, Hao Kaige, Liu Lian, Wu Boqing, Zheng Xinyue, Xiao Bo, Tong Xiaoling, Fangyin Dai§. Topical application of silk fibroin-based hydrogel in preventing hypertrophic scars. Colloids and Surfaces B-Biointerfaces. 2019, 186: 110735.
授权专利：
[1] 专利权人：代方银、宋江波、李知泉、陈欣、童晓玲、周磊、韩民锦、胡海，专利名称：OSER1基因在提升动物生殖力或延缓生殖衰老中的应用和方法，专利类型：发明专利，授权号：ZL 2022 1 0988437.5，授权时间：2024-04-05，国别：中国。
学术报告：
1. 2024 Conference on Healthy Aging, Chongqing, China, Topic: Silkworm: a promising experimental animal for aging and lifespan study, June 17th-19th, 2024.
2. 2023 SWU-UCPH Bilateral Academic Conference, Chongqing, China, Topic: The progress in silkworm experimental Biological Systems, October 19th-23rd, 2023.
3. The 7th Asia-Pacific Congress of Sericulture and Insect Biotechnology, Zhenjiang, China, Topic: FOXO-regulated OSER1 reduces oxidative stress and extends lifespan in multiple species, August 18th-22nd, 2023.
4. The 6th Asia-Pacific Congress of Sericulture and Insect Biotechnology, Mysore, India, Topic: Death-3, a newly identified FoxO target regulates lifespan in silkworm, Bombyx mori, March 1st-5th, 2019.
5. The Sino-Korea Joint Symposium on Insect Molecular Biology and Biotechnology, Jiangsu, China, Topic: Identification of FoxO target gene OSER1 and its functional study on lifespan in silkworm, Bombyx mori. December 6th-8th, 2019.
6. 第九届中国蚕学会青年学术研讨会，重庆，中国，报告题目：BmFoxO基因调控寿命的初步研究。2017年10月。
学术任职：
1. 重庆市昆虫学会，理事，2023.09-至今
2. 中国遗传学会，会员，2023.11-至今
3. 农业生物技术学报，青年编委，2024.01-至今
4. 国家蚕桑产业技术体系高产优质品种改良岗位团队成员，2023.01 -至今
5. 担任BMC Genomics等期刊审稿人
