教 师 简 历

照片/Photo：

电子邮箱/E-mail：ylzoucau@163.com

邹云龙

博士，副教授，硕导

本科生课程：

《基因工程》、《遗传学》（英文）、《生命科学前沿讲座》（主持）

科研项目：主持国家自然科学基金青年基金项目、中央高校基本科研业务费

研究方向关键词：基因编辑、昆虫化学感受、家蚕发育生物学

主要科研贡献：

（1）高效基因编辑工具的开发与优化。在家蚕中，建立了高效的基于核糖核蛋白的CRISPR/Cas9和CRISPR/Cas12a (Cpf1) 基因编辑系统。利用遗传修饰手段（基因编辑、转基因）解析重要基因的功能、探究调控机制、创制育种素材。

（2）众所周知，家蚕主要以桑叶为食，对桑叶具有特殊的偏好。我们对其遗传基础及调控机制进行了深入研究，挖掘了多个参与家蚕食性调控的嗅觉受体、味觉受体、转录因子，并通过基因编辑创制了对人工饲料优异适应性的育种素材。

发表论文 (^#共同一作, *通讯作者)：

[1] Yunlong Zou; Wentao Wu; Tianfu Luo; Yuxia Tang; Hai Hu; Aijun Ye; Lifeng Xu; Fangyin Dai*; Xiaoling Tong*. Disruption of Zfh3 abolishes mulberry-specific monophagy in silkworm larvae, Insect Science, 2024, doi: 10.1111/1744-7917.13354.

[2] Yun-Long Zou^#; Xin Ding^#; Li Zhang^#; Li-Feng Xu; Shu-Bo Liang; Hai Hu; Fang-Yin Dai; Xiao-Ling Tong*. Bmmp influences wing morphology by regulating anterior-posterior and proximal-distal axes development, Insect Science, 2022, 29(6):1569-1582.

[3] Yun-long Zou; Ai-jun Ye; Shuo Liu; Wen-tao Wu; Li-feng Xu; Fang-yin Dai; Xiao-ling Tong*. Expansion of targetable sites for the ribonucleoprotein-based CRISPR/Cas9 system in the silkworm Bombyx mori, BMC Biotechnology, 2021, 21(1): 54

[4] Yunlong Zou; Haiyang Hao; Ning Li; Qiuyan Li*. Establishment and characterization of immortalized porcine neonatal hepatocytes without the use of viral components, In Vitro Cellular & Developmental Biology-Animal, 2020, 56 (1): 75-84

[5] ZOU Yun-long; LI Zhi-yuan; ZOU Yun-jing; HAO Hai-yang; HU Jia-xiang; LI Ning; LI Qiu-yan*. Generation of pigs with a Belgian Blue mutation in MSTN using CRISPR/Cpf1-assisted ssODN-mediated homologous recombination, Journal of Integrative Agriculture, 2019, 18(6): 1329-1336

[6] Yunlong Zou; Zhiyuan Li; Yunjing Zou; Haiyang Hao; Ning Li; Qiuyan Li*. An FBXO40 knockout generated by CRISPR/Cas9 causes muscle hypertrophy in pigs without detectable pathological effects, Biochemical and Biophysical Research Communications, 2018, 498(4): 940-945

[7] Yunlong Zou; Yanjun Dong; Qingyong Meng; Yaofeng Zhao*; Ning Li*. Incorporation of a skeletal muscle-specific enhancer in the regulatory region of Igf1 upregulates IGF1 expression and induces skeletal muscle hypertrophy, Scientific Reports, 2018, 8(1): 2781

[8] Tingting Gai^#; Xiaoling Tong^#*; Minjin Han; Chunlin Li; Chunyan Fang; Yunlong Zou; Hai Hu; Hui Xiang; Zhonghuai Xiang; Cheng Lu; Fangyin Dai*. Cocoonase is indispensable for Lepidoptera insects breaking the sealed cocoon, PLoS Genetics, 2020, 16(9)

[9] Jingyao Chen; Haitao Wang; Jianhui Bai; Wenjie Liu; Xiaojuan Liu; Dawei Yu; Tao Feng; Zhaolin Sun; Linlin Zhang; Linyuan Ma; Yiqing Hu; Yunlong Zou; Tan Tan; Jie Zhong; Man Hu; Xiaofei Bai; Dengke Pan; Yiming Xing; Yaofeng Zhao; Kegong Tian*; Xiaoxiang Hu*; Ning Li*. Generation of Pigs Resistant to Highly Pathogenic-Porcine Reproductive and Respiratory Syndrome Virus through Gene Editing of CD163, International Journal of Biological Sciences, 2019, 15(2): 481-492