教 师 简 历

基本信息

照片/Photo：    

电子邮箱/E-mail：bxiao@swu.edu.cn

个人简介

肖波，教授、博士生导师，生物技术系主任。先后入选“全球顶尖前10万科学家排名”榜单、“2020全球前2%顶尖科学家”、国家级青年人才计划和重庆市委组织部“青年拔尖人才”等。

课程教学

本科生课程：

《细胞生物学》、《生命科学进展》、《细胞生化及分子生物学》

研究方向及课题

口服纳米医学：基于植物（如桑叶、茶叶等）、蚕丝蛋白（丝素、丝胶等）和合成高分子的药用功能和特殊理、化性能，我们试图利用其作为天然纳米药物或药物（如siRNA、pDNA、化学药物等）的载体材料，设计并构建各种新型纳米粒子、微米粒子、水凝胶或纤维等载药系统，用于多种炎症性疾病和肿瘤的诊断、预防和治疗。近年来，以唯一通讯作者或最后一位通讯作者在Gastroenterology、ACS nano、Advanced Drug Delivery Review、Acta Pharm. Sin. B、Biomaterials、Journal of Controlled Release、 Theranostics、Molecular Therapy和ACS Applied Materials & Interfaces等国际顶级或权威杂志上发表学术论文50余篇。先后主持国家高层次人才项目、国家自然科学基金（3项）、重庆市自然科学基金和美国心脏协会基金等项目。

研究成果

[1] Ya Ma, Lian Duan, Jianfeng Sun, Shuangquan Gou, Fengyuan Chen, Yuqi Liang, Fangyin Dai, Bo Xiao*. Oral nanotherapeutics based on Antheraea pernyi silk fibroin for synergistic treatment of ulcerative colitis. Biomaterials 2022;282: 21410.（IF = 12.4）

[2] Shuangquan Gou, Nanxi Chen, Xiaoai Wu, Menghang Zu, Shixiong Yi, Binwu Ying*, Fangyin Dai, Bowen Ke*, Bo Xiao*. Multi-responsive nanotheranostics with enhanced tumor penetration and oxygen self-producing capacities for multimodal synergistic cancer therapy. Acta Pharm. Sin. B 2022;12(1):406-423. (IF = 11.4） 

[3] Chen Q., Li Q., Liang Y., Zu M., Chen N., Canup B., Luo L., Wang C.*, Zeng L.*, and Xiao B.* Natural exosome-like nanovesicles from edible tea flowers suppress metastatic breast cancer via ROS generation and microbiota modulation. Acta Pharm. Sin. B 2022;12(2):907-923.   (IF = 11.4） 

[4] Menghang Zu, Dengchao Xie, Brandon S.B. Canup, Nanxi Chen, Yajun Wang, Ruxin Sun, Zhan Zhang, Yuming Fu,* Fangyin Dai,* and Bo Xiao*. ‘Green’ nanotherapeutics from tea leaves for orally targeted prevention and alleviation of colon diseases. Biomaterials 2021; 279: 121178. （IF = 12.4）

[5] Zu M., Ma Y., Cannup B., Xie D., Jung Y., Zhang J., Yang C., Gao F.*, Merlin D.*, and Xiao B.*. Oral delivery of natural active small molecules by polymeric nanoparticles for the treatment of inflammatory bowel diseases. Adv. Drug Deliv. Rev. 2021;176:113887. (IF = 15.4） 

[6] Zhang X., Huang Y., Song H., Canup B.S.B., Gou S., She Z., Dai F.*, Ke B.*, and Xiao B.*. Inhibition of growth and lung metastasis of breast cancer by tumor-homing triple-bioresponsive nanotherapeutics. Journal of Controlled Release 2020;328:454-469. （IF = 9.7） 

[7] Gou S., Yang J., Ma Y., Zhang X., Zu M., Kang T., Liu S., Ke B.*, and Xiao B.*. Multi-responsive nanococktails with programmable targeting capacity for imaging-guided mitochondrial phototherapy combined with chemotherapy. Journal of Controlled Release 2020;327: 371-383. （IF = 9.7） 

[8] Gou S., Huang Y., Wan Y., Ma Y., Zhou X., Tong X., Huang J.*, Kang Y.*, Pan G., Dai F., and Xiao B.*. Multi-bioresponsive silk fibroin-based nanoparticles with on-demand cytoplasmic drug release capacity for CD44-targeted alleviation of ulcerative colitis. Biomaterials 2019; 212:39-54. （IF = 12.4）

[9] Xiao B.*, Laroui H., Viennois E., Ayyadurai S., Charania M.A., Zhang Y., Zhang Z., Baker M.T., Zhang B., Gewirtz A.T., and Merlin D.. Nanoparticles with surface antibody against CD98 and carrying CD98 small interfering RNA reduce colitis in mice. Gastroenterology 2014; 146(5):1289-1300.（IF = 22.6）

[10] Xiao B.*, Viennois E., Chen Q., Wang L., Han M., Zhang Y., Zhang Z., Kang Y., Wan Y., and Merlin D.. Silencing of Intestinal Glycoprotein CD98 by Orally Targeted Nanoparticles Enhances Chemosensitization of Colon Cancer. ACS nano 2018;12:5253-5265.（IF = 15.8）